Prostate-Specific Antigen and Perfluoroalkyl Acids in the C8 Health Study Population

PURPOSE To inform questions raised by inconsistent findings regarding an association between perfluoroalkyl acids (PFAAs) and prostate cancer by assessing the relationship of PFAAs in human serum to prostate-specific antigen (PSA). MATERIALS AND METHODS Using 2005 to 2006 survey data from a large survey population, we compared serum PFAA concentrations in adult males with PSA concentrations adjusted for risk factors including age, body mass index, smoking status, and socioeconomic status. RESULTS Perfluoroalkyl acids are not consistently associated with PSA concentration in general, or with PSA more than 4.0. DISCUSSION These findings do not provide evidence that PFAA exposure is associated with PSA.